| DING Hao,ZHANG Zixin,ZHAO Xueyu,TIAN Shiyu,KUANG Ruizhi,SHEN Lingwei,WANG Shuyao,WANG Jin,ZHAO Yuancong,LI Xin.Research Progress of Drug-coated Balloons[J],53(23):16-30 |
| Research Progress of Drug-coated Balloons |
| Received:September 27, 2024 Revised:November 29, 2024 |
| View Full Text View/Add Comment Download reader |
| DOI：10.16490/j.cnki.issn.1001-3660.2024.23.002 |
| KeyWord:drug-coated balloons excipient coating method smart balloon responsiveness nanomotor |
| Author | Institution |
| DING Hao |
Chengdu Third People's Hospital, Affiliated Hospital of Southwest Jiaotong University, Chengdu , China;a.College of Medicine,hengdu , China |
| ZHANG Zixin |
Chengdu Third People's Hospital, Affiliated Hospital of Southwest Jiaotong University, Chengdu , China;a.College of Medicine,hengdu , China |
| ZHAO Xueyu |
School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu , China |
| TIAN Shiyu |
School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu , China |
| KUANG Ruizhi |
School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu , China |
| SHEN Lingwei |
a.College of Medicine,hengdu , China |
| WANG Shuyao |
Chengdu Third People's Hospital, Affiliated Hospital of Southwest Jiaotong University, Chengdu , China;a.College of Medicine,hengdu , China |
| WANG Jin |
a.College of Medicine,hengdu , China |
| ZHAO Yuancong |
a.College of Medicine,hengdu , China |
| LI Xin |
Chengdu Third People's Hospital, Affiliated Hospital of Southwest Jiaotong University, Chengdu , China;a.College of Medicine,hengdu , China |
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| Abstract: |
| This paper reviews the optimization of antiproliferative drugs, the innovations in excipients, the improvements in coating methods, and the smart drug-coated balloons (DCB). Advantages, disadvantages, and future optimization of two commonly used antiproliferative drugs, paclitaxel (PTX) and sirolimus and its derivatives are presented. The mechanism of action and future application prospects of iopromide, polyethylene oxide (PEO), citrate, and keratose (KOS) as excipients are described. Then, coating methods, such as the micropipette method, the dip coating method, the brush coating method, and the spray coating method, are outlined, and their advantages and disadvantages are explained. Then, it is followed by a brief description of the combination of smart response technology and DCB, which introduces the principles of action and potential applications of smart DCB such as ultrasound-responsive, light-driven, gas-driven, reactive oxygen species (ROS)-responsive, and microneedle (MN) coatings. Finally, based on the above, the problems of DCB are analyzed, and the future development direction of DCB is projected. |
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