| SONG Li-yun,A Na-ri,LIU Yang,BAO Sa-ru-la,WANG Ye-ling.Research Progress of on Processing and Modification Methods of Degradable Magnesium Zinc Alloy Scaffolds[J],52(8):129-141 |
| Research Progress of on Processing and Modification Methods of Degradable Magnesium Zinc Alloy Scaffolds |
| Received:May 04, 2022 Revised:June 20, 2022 |
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| DOI：10.16490/j.cnki.issn.1001-3660.2023.08.008 |
| KeyWord:bioresorbable vascular scaffolds Mg-Zn alloy improved technology biocompatibility surface modification |
| Author | Institution |
| SONG Li-yun |
The First Hospital of Jilin University, Changchun , China |
| A Na-ri |
The First Hospital of Jilin University, Changchun , China |
| LIU Yang |
The First Hospital of Jilin University, Changchun , China |
| BAO Sa-ru-la |
The First Hospital of Jilin University, Changchun , China |
| WANG Ye-ling |
The First Hospital of Jilin University, Changchun , China |
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| Abstract: |
| Drug-eluting stents are currently the preferred material in the stent treatment of coronary heart disease, but their permanent presence in the body will damage endothelial cells, stent thrombosis, restenosis, etc. These disadvantages gradually become apparent with years of extensive use. Bioresorbable scaffold materials can provide temporary support for blood vessels, and can be completely degraded in the body after the task is completed, so that blood vessels can restore their original appearance. Its unique advantages become the future development direction of cardiac vascular stents. At present, polymer and magnesium are mainly used in the research of bioresorbable scaffold materials. However, bioresorbable polymer scaffolds are limited in the field of biodegradable scaffolds due to insufficient radial support, difficulty in observation and high risk of thrombosis. As a new member of the bioresorbable vascular scaffolds, due to their biosafety and mechanical properties similar to those of traditional metal stents, the bioresorbable magnesium-zinc alloy scaffold has been favored by many research institutions in China and abroad. Firstly, the good biocompatibility of magnesium and zinc is introduced. They are abundant elements in the human body and play an important role in a variety of life activities. A lack of magnesium or zinc can increase the risk of human diseases such as cardiovascular diseases. If magnesium and zinc are combined, their undesirable properties can be improved to bring them closer to the need for biodegradable materials. However, the local high concentration of degradation products, mechanical properties and degradation rate control mechanism of Mg-Zn alloy scaffolds need to be further improved. In view of these problems, the improvement measures in recent years are discussed. The techniques commonly used to improve Mg-Zn alloy materials include addition of other elements, surface modification, heat treatment, plastic processing, rapid solidification, combination of various technologies, etc. Among these methods, surface modification is considered as a major category, including chemical transformation, anodic oxidation, electrochemical deposition, plasma spraying, ion implantation, physical vapor deposition, laser technology, sol-gel and other methods. It has been proved by many researchers that the properties of Mg-Zn alloy can be improved effectively by one or more techniques combined with suitable parameters. The principles of these improved technologies are summarized, the effects are illustrated with examples, and the limitations as biodegradable vascular scaffolds are explored. The surface modification is the main method in the improved technology. Through the mechanical, physical, chemical and biological-chemical method in preparation of surface coating, this technique has simple preparation method, does not affect performance alloy itself and can improve the overall performance alloy. It is outstanding in improving the initial corrosion resistance of alloys. However, many methods have shortcomings such as high brittleness and loose structure. The addition of some other metals or rare earth elements, heat treatment, plastic processing, rapid solidification can also effectively improve the mechanical properties and corrosion resistance of Mg-Zn alloy and enhance its biocompatibility. However, the method of adding elements is expensive, and it is difficult to control the uniform surface corrosion. Heat treatment and plastic processing can not fully control the galvanic corrosion in the alloy. Rapid solidification can refine grain size and reduce impurities, but the alloy still has different degrees of oxidation. The combination of a variety of methods can be used to check and fill gaps, which has a more prominent advantage in improving the overall performance of alloy. Finally, the future development of biodegradable Mg-Zn alloy scaffolds is prospected. |
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