| LIU Ying,YANG Rui,LIU Jing-lai,LIU Jia-xin,ZHANG Jing-ling.Hydroxyapatite Nanomaterials Doped with Single-phase,Dual-phase and Multiphase Ions[J],51(10):143-154 |
| Hydroxyapatite Nanomaterials Doped with Single-phase,Dual-phase and Multiphase Ions |
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| DOI：10.16490/j.cnki.issn.1001-3660.2022.10.014 |
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| Author | Institution |
| LIU Ying |
College of Science,Liaoning Fuxin , China |
| YANG Rui |
College of Materials Science and Engineering, Liaoning Technical University, Liaoning Fuxin , China |
| LIU Jing-lai |
Ganli Pharmaceutical Co., Ltd., Beijing , China |
| LIU Jia-xin |
College of Materials Science and Engineering, Liaoning Technical University, Liaoning Fuxin , China |
| ZHANG Jing-ling |
College of Materials Science and Engineering, Liaoning Technical University, Liaoning Fuxin , China |
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| Abstract: |
| Hydroxyapatite is an important part of natural bone tissue composition and has always been the focus of attention and research in the field of biomedicine. The apatite in the natural bone composition is a kind of hydroxyapatite combined with a variety of ions, which maintains the normal growth and development of life systems. With the systematic research on single-phase ion doping, the preparation and performance of dual-phase and multi-phase doped hydroxyapatite are being continuously expanded. The preparation and performance of phase and heterogeneous ion-doped hydroxyapatite are systematically elaborated and summarized.This study expounds the crystal structure of hydroxyapatite, describes the advantages and performance advantages of synthetic hydroxyapatite itself, hydroxyapatite with good biological properties as a coating has been widely used in experiments to replace bone, but Some performance deficiencies limit its application. The study outlines the researchers' research on the effects of different ion doping or different forms of doping on the properties of hydroxyapatite, including biocompatibility, biological activity, suitable mechanical strength, excellent bone formation performance and corrosion resistance performance. At the same time, the different substitution sites of anion and cation doped hydroxyapatite are summarized.On this basis, starting from the preparation and performance research of single-phase ion-doped hydroxyapatite, the performance changes caused by different ion doping and the corresponding mechanism are explained. Prospects and shortcomings. Based on the single-phase ion-doped hydroxyapatite in the past five years, it is necessary to explore the effects of two-phase and multi-phase ion-doped hydroxyapatite on the structural properties, mechanical strength, antibacterial properties, degradability, and osteogenic properties. A certain pavement. At the same time, two-phase and multi-phase ion doping of hydroxyapatite found that the doping ions will promote each other. By doping hydroxyapatite in different phases, it is found that the performance of multi-phase doping is based on the synergistic effect of single-phase or multi-phase doping. In addition, the doping of hydroxyapatite with trace ions can promote the activity of bone cells, promote the growth, proliferation and differentiation of bone cells, and thus play a role in inducing bone formation. However, doping with different ions will produce different properties. The doping of hydroxyapatite with magnesium, iron, zinc, strontium, and fluorine will produce different degrees of antibacterial properties against Escherichia coli or Staphylococcus aureus. Part of the ions doped with hydroxyapatite will increase the mechanical properties of the material and increase the degradation performance.Through more systematic preparation and performance research of single-phase and dual-phase doped hydroxyapatite, a more effective preparation method has been explored for realizing multiphase doped hydroxyapatite. In recent years, although hydroxyapatite bioceramic materials have been used clinically as implant coatings, sustained-release drug carriers, and bone graft replacement materials, they still face many problems and challenges in their widespread use in clinical practice. Therefore, this article also looks forward to the future development direction of ion-doped hydroxyapatite, paving the way for exploring the preparation method and performance of heterogeneous ion-doped hydroxyapatite, making the preparation closer to natural crystal structure and performance The bionic bone material of apatite is expected to have certain guiding significance in clinical application and development. |
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