| JING Pei-pei,ZHANG Yue,LUO Xiao-yu,GONG Yan-li,FENG Qing-guo,LENG Yong-xiang,DENG Qiao-yuan.Adsorption, Denaturation and Decomposition of Proteins in Friction Interface for Artificial Hip Joint and Molecular Mechanism of Formation of Graphite-like Carbon Lubrication Layer[J],49(6):52-59 |
| Adsorption, Denaturation and Decomposition of Proteins in Friction Interface for Artificial Hip Joint and Molecular Mechanism of Formation of Graphite-like Carbon Lubrication Layer |
| Received:June 12, 2020 Revised:June 20, 2020 |
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| DOI：10.16490/j.cnki.issn.1001-3660.2020.06.006 |
| KeyWord:artificial joint frictional interface biofilm graphite-like carbon lubrication layer transition metal reactive oxygen species |
| Author | Institution |
| JING Pei-pei |
1.School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu , China |
| ZHANG Yue |
1.School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu , China |
| LUO Xiao-yu |
1.School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu , China |
| GONG Yan-li |
1.School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu , China |
| FENG Qing-guo |
1.School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu , China |
| LENG Yong-xiang |
1.School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu , China |
| DENG Qiao-yuan |
2.School of Materials Science and Engineering, Hainan University, Haikou , China |
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| Abstract: |
| Artificial joint replacement is considered to be the most effective and ultimate treatment for joint diseases such as advanced arthritis and joint dysfunction. The in vivo service environment characteristics of artificial hip joint, and the formation of biofilm and graphite-like carbon lubrication layer in friction interface were introduced firstly. The denaturation and degradation of proteins at the friction interface catalyzed by transition metal copper under the simulated in vivo service environment were further discussed and the transformation from biofilm to graphite-like carbon lubrication layer was also investigated. The molecular mechanism of transition metal ions producing reactive oxygen species, catalyzing the adsorption, denaturation and decomposition of proteins and forming biofilm, graphite-like carbon lubrication layer was studied, and the design of ceramic artificial joint material was prospected. |
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