戴宇航,陈江太,赵晖,林祥德,廖跃华,谢美华.医用镁合金超疏水PDMS/H-SiO2涂层的制备及耐蚀性研究[J].表面技术,2024,53(24):69-78.
DAI Yuhang,CHEN Jiangtai,ZHAO Hui,LIN Xiangde,LIAO Yuehua,XIE Meihua.Superhydrophobic PDMS/H-SiO2 Coatings on Medical Magnesium Alloys with Anti-corrosion Properties[J].Surface Technology,2024,53(24):69-78 |
| 医用镁合金超疏水PDMS/H-SiO2涂层的制备及耐蚀性研究 |
| Superhydrophobic PDMS/H-SiO2 Coatings on Medical Magnesium Alloys with Anti-corrosion Properties |
| 投稿时间：2023-12-18 修订日期：2024-02-21 |
| DOI：10.16490/j.cnki.issn.1001-3660.2024.24.006 |
| 中文关键词: 医用镁合金 表面处理 超疏水涂层 耐腐蚀性 血液相容性 |
| 英文关键词:medical magnesium alloys surface treatment superhydrophobic coatings anti-corrosion blood compatibility |
| 基金项目:国家自然科学基金(22008151);上海市青年科技英才扬帆计划(20YF1418000) |
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| Author | Institution |
| DAI Yuhang | School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China;Shanghai University of Medicine & Health Sciences, Shanghai 201318, China |
| CHEN Jiangtai | Shanghai University of Medicine & Health Sciences, Shanghai 201318, China |
| ZHAO Hui | Shanghai University of Medicine & Health Sciences, Shanghai 201318, China |
| LIN Xiangde | Shanghai University of Medicine & Health Sciences, Shanghai 201318, China |
| LIAO Yuehua | Shanghai University of Medicine & Health Sciences, Shanghai 201318, China |
| XIE Meihua | Shanghai University of Medicine & Health Sciences, Shanghai 201318, China |
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| 中文摘要: |
| 目的 在镁合金表面构建超疏水涂层，以降低镁合金材料的降解速率，减少血小板黏附，提高镁合金的血液相容性。方法 采用迈耶棒刮涂聚二甲基硅氧烷和网筛二氧化硅颗粒的方法在镁合金表面制备超疏水复合涂层。采用扫描电子显微镜、红外光谱、能量色散谱仪等测试方法对涂层进行表征;使用接触角测量仪检测涂层的疏水性;通过电化学测试研究涂层耐蚀性;通过体外血小板黏附和疏血性测试评价分析血液相容性。结果 通过刮涂网筛聚二甲基硅氧烷和网筛二氧化硅颗粒制备的涂层在AZ31B镁合金表面呈现均匀且致密的形态。在3.5%(质量分数)的氯化钠溶液中浸泡后，相比于对照组裸AZ31B镁合金和仅涂覆PDMS的镁合金，涂层电阻(2.85×106 Ω.cm2)和电荷转移电阻(5.69×106 kΩ.cm2)都为最大值，复合涂层的腐蚀电流密度相比镁合金降低了5个数量级，腐蚀电压为正值，呈现出优异的耐腐蚀性;复合涂层表面无黏附血小板，血液接触角大于150°，呈现超疏血性。结论 综上所述，通过简单的涂层技术制备了一种超疏水复合涂层，复合涂层覆盖的镁合金展现出优越的耐腐蚀性能和优异的血液相容性，为拓宽镁合金的应用提供了一种新的防腐策略。 |
| 英文摘要: |
| Due to good biocompatibility and degradability, magnesium alloy has become a key research object in the development of coronary stents and other medical devices. There is a problem to limit the biomedical application of magnesium alloy for too fast degradation rate. In order to improve the corrosion resistance of magnesium alloys, different protection technologies have been proposed such as chemical composition, microstructure and surface modification, mainly including alloying, anodizing, micro-arc oxidation, electrodeposition and superhydrophobic coating. The superhydrophobic coating is a method that significantly improves corrosion resistance by constructing an insulating layer to reduce the contact area and contact time between the corrosive medium and the substrate material. A superhydrophobic surface modification of magnesium alloy will be carried out to reduce the degradation rate of magnesium alloy and platelet adhesion. In order to improve the anti-corrosion property of AZ31B magnesium alloy and obtain better hemocompatibility, a superhydrophobic coating was scrapped on magnesium alloy with polydimethylsiloxane by Meyer rod and sieved silica particles. Scanning electron microscopy (SEM) was used to characterize the surface morphology of the coating and SEM-EDS mapping was used to analyze its surface element distribution. The characteristic peaks of the composite coating were characterized by infrared spectroscopy to determine their chemical structure. The contact angle measuring instrument was used to test the hydrophobicity of the coating. The anti-corrosion performance of composite coating on magnesium alloy was tested through electrochemical testing. Hemocompatibility was analyzed by in vitro platelet adhesion and hemophorecity test evaluation. The SEM images showed that the composite coating prepared by the scraping was a uniform and dense form on the surface of AZ31B magnesium alloy. The PDMS/H-SiO2 composite coating surface presented a micron-scale particle under high magnification. The rough morphology helped to form superhydrophobic surface. The coating including silicon, oxygen and carbon elements could be known through EDS data. The infrared spectroscopy results confirmed that the composition of composite coating was PDMS and SiO2. After soaking in 3.5wt.% sodium chloride solution, compared with the control group of bare AZ31B magnesium alloy and PDMS-only coated magnesium alloy, the capacitance of composite coating (1.56 × 10−7 F/cm2) was the minimum value and the resistance (2.85 × 106 Ω.cm2) and charge transfer resistance (5.69 × 106 kΩ.cm2) were the maximum values. The corrosion current density of the composite coating was reduced by five orders of magnitude compared with that of the magnesium alloy, and the corrosion voltage was positive. In conclusion, excellent corrosion resistance was shown by corrosion inhibition efficiency of 99.99%. Additionally, there were no adherent platelets on the surface of the composite coating, and the blood contact angle was greater than 150°, showing super-hydrophobicity. In summary, a simple and excellent superhydrophobic composite coating is prepared to improve the corrosion resistance of magnesium alloys. The composite surface exhibits superhydrophobicity and excellent hemocompatibility. It provides a new anti-corrosion strategy for broadening the application of magnesium alloys. |
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