金荷渊,付伟豪,曹佳乐,张向宽,宋鑫忠,刁统祥,满佳.制备简单的润滑、抗菌两性离子/阳离子聚合物刷涂层[J].表面技术,2024,53(23):88-96.
JIN Heyuan,FU Weihao,CAO Jiale,ZHANG Xiangkuan,SONG Xinzhong,DIAO Tongxiang,MAN Jia.Lubricating, Antimicrobial Zwitterionic/Cationic Polymer Brush Coatings Prepared by Simple Methods[J].Surface Technology,2024,53(23):88-96 |
| 制备简单的润滑、抗菌两性离子/阳离子聚合物刷涂层 |
| Lubricating, Antimicrobial Zwitterionic/Cationic Polymer Brush Coatings Prepared by Simple Methods |
| 投稿时间：2024-09-09 修订日期：2024-11-19 |
| DOI：10.16490/j.cnki.issn.1001-3660.2024.23.007 |
| 中文关键词: 导尿管 抗菌 润滑 聚合物刷 两性离子 阳离子 |
| 英文关键词:urinary catheters antimicrobial lubrication polymer brushes zwitterionic polymers cationic polymers |
| 基金项目:国家自然科学基金(52375191);国家重点研发计划(2020YFC1512703);山东省泰山学者项目(tsqn202211031) |
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| Author | Institution |
| JIN Heyuan | School of Mechanical Engineering,Key Laboratory of Efficient and Clean Machinery Manufacturing, Ministry of Education, Shandong University, Jinan 250061, China |
| FU Weihao | School of Mechanical Engineering,Key Laboratory of Efficient and Clean Machinery Manufacturing, Ministry of Education, Shandong University, Jinan 250061, China |
| CAO Jiale | School of Mechanical Engineering,Key Laboratory of Efficient and Clean Machinery Manufacturing, Ministry of Education, Shandong University, Jinan 250061, China |
| ZHANG Xiangkuan | School of Mechanical Engineering,Key Laboratory of Efficient and Clean Machinery Manufacturing, Ministry of Education, Shandong University, Jinan 250061, China |
| SONG Xinzhong | School of Mechanical Engineering,Key Laboratory of Efficient and Clean Machinery Manufacturing, Ministry of Education, Shandong University, Jinan 250061, China |
| DIAO Tongxiang | Department of Urology, Affiliated Provincial Hospital of Shandong First Medical University, Jinan 250021, China |
| MAN Jia | School of Mechanical Engineering,Key Laboratory of Efficient and Clean Machinery Manufacturing, Ministry of Education, Shandong University, Jinan 250061, China |
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| 中文摘要: |
| 目的 避免导尿管引起的细菌感染与摩擦损伤。方法 开发一种简单的主被动结合的基于甲基丙烯酰乙基磺基甜菜碱(SBMA)亲水两性离子材料和甲基丙烯酰氧乙基三甲基氯化铵(DMC)阳离子材料的聚合物刷抗菌涂层策略。通过紫外光引发接枝方法，一步聚合SBMA单体与DMC单体形成混合的PSBMA/DMC聚合物刷涂层，并调控聚合单体溶液中SBMA与DMC的摩尔比，制备不同类型的PSBMA/DMC聚合物刷涂层。通过表面水接触角测试、AFM摩擦测试、蛋白质黏附测试与细菌黏附测试等分别表征对比各聚合物刷涂层的润湿性、润滑性、抗蛋白黏附性及抗菌效果。结果 在PSBMA/DMC涂层中，SBMA含量越高，表面润湿性越强，表面润滑性越强。在只含有SBMA的PSBMA/DMC-100聚合物刷涂层表面，细菌的黏附量下降了96.1%，但黏附的少量细菌均为活细菌，这对于其长效抗菌性的实现是不利的。SBMA占比25%，DMC占比75%的PSBMA/DMC-25混合聚合物刷涂层能通过结合主被动抗菌策略实现良好的抗菌效果，细菌黏附量下降了92%，且黏附的细菌全部死亡，这使其具有长效抗菌的潜力。结论 两性离子与阳离子材料混合的聚合物刷涂层制备过程简单，结合主被动抗菌策略，兼顾表面润滑特性和抗菌性能，有望解决导尿管面临的细菌感染以及摩擦损伤问题，并在相关医疗器械表面涂层领域中具有潜在的应用前景。 |
| 英文摘要: |
| Urethral catheters are indispensable medical devices for patients with urinary incontinence, urinary retention, and other urinary disorders. However, the outer surface of the catheter currently faces the problem of urinary tract infection in patients due to bacterial adherence. In addition, in clinical treatment, catheters need to be in frequent contact with body tissues either for a long or short period of time. And due to the large friction coefficient between the surface of the catheter and muscle tissues, the patient will experience varying degrees of burning pain each time when the tissues are inserted or withdrawn, which is prone to cause the corresponding mucosal damage and even tissue inflammation. Therefore, the development of catheters that are antimicrobial, inhibit bacterial aggregation and biofilm attachment, and have a lubricating effect, which is an urgent problem that needs to be solved. In order to avoid bacterial infections and friction damage complications that may occur when using urinary catheters. This paper described the development of a novel polymer brush antimicrobial coating strategy. This strategy copolymerized methacryloyloxyethyl sulfobetaine (SBMA) zwitterionic material and methacryloyloxyethyl trimethyl ammonium chloride (DMC) cationic material to form a polymer brush coating. This strategy combined the passive antimicrobial principle of resisting bacterial adhesion and the active antimicrobial principle of killing bacteria. Various PSBMA/DMC polymeric brush coatings were synthesized by a single-step polymerization process, in which the SBMA and DMC monomers were polymerized by UV-initiated grafting, and the molar ratios of SBMA and DMC in the polymerized monomer solutions were varied. |
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