王镔彬,张皓,申孝龙,王海波,杨成,范兴平,杨晓凤,杨宇松,吴邦杰,周清瑞.镁基骨植入物表面改性研究进展[J].表面技术,2024,53(23):61-77.
WANG Binbin,ZHANG Hao,SHEN Xiaolong,WANG Haibo,YANG Cheng,FAN Xingping,YANG Xiaofeng,YANG Yusong,WU Bangjie,ZHOU Qingrui.Research Progress on Surface Modification of Magnesium-based Bone Implants[J].Surface Technology,2024,53(23):61-77 |
| 镁基骨植入物表面改性研究进展 |
| Research Progress on Surface Modification of Magnesium-based Bone Implants |
| 投稿时间：2024-05-20 修订日期：2024-07-25 |
| DOI：10.16490/j.cnki.issn.1001-3660.2024.23.005 |
| 中文关键词: 镁合金 骨植入物 表面改性 生物功能性 |
| 英文关键词:magnesium alloys bone implants surface modification biological functionality |
| 基金项目:国家自然科学基金(52101286);四川省中央引导地方科技发展专项项目(2023ZYD0115);国家级大学生创新创业训练计划(202411360008);攀枝花学院研究生创新计划(y2024024) |
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| Author | Institution |
| WANG Binbin | Vanadium and Titanium College,Sichuan Panzhihua 617000, China |
| ZHANG Hao | Vanadium and Titanium College,Sichuan Panzhihua 617000, China;Sichuan Provincial Key Laboratory of Comprehensive Utilization of Vanadium and Titanium Resources, Sichuan Panzhihua 617000, China |
| SHEN Xiaolong | College of Biological and Chemical Engineering, Panzhihua University, Sichuan Panzhihua 617000, China |
| WANG Haibo | Vanadium and Titanium College,Sichuan Panzhihua 617000, China |
| YANG Cheng | Vanadium and Titanium College,Sichuan Panzhihua 617000, China |
| FAN Xingping | Vanadium and Titanium College,Sichuan Panzhihua 617000, China |
| YANG Xiaofeng | Vanadium and Titanium College,Sichuan Panzhihua 617000, China |
| YANG Yusong | Vanadium and Titanium College,Sichuan Panzhihua 617000, China |
| WU Bangjie | Vanadium and Titanium College,Sichuan Panzhihua 617000, China |
| ZHOU Qingrui | Vanadium and Titanium College,Sichuan Panzhihua 617000, China |
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| 中文摘要: |
| 镁基骨植入物是一种用于骨固定或骨修复的新型生物可降解材料。概述了骨植入器械临床需求，镁及其合金作为骨植入物的材料优势，以及镁基骨植入物的体内应用环境。同时，阐述了镁基骨植入物临床应用存在的问题，包括过快的降解速率和生物相容性问题。在此基础上，重点综述了近年来镁基骨植入物表面改性研究进展，按涂层功能分为耐腐蚀涂层(微弧氧化涂层、溶胶-凝胶涂层、水热涂层及低温等离子聚合涂层)、促骨自愈合涂层(骨愈合药物涂层、类骨生物活性物质涂层)、抗菌涂层(金属离子或氧化物涂层、抗菌药物涂层)、自修复涂层(自发式涂层、触发式涂层)及生物免疫性涂层(免疫活性物质涂层)等。针对各种功能的表面改性涂层，分别从制备方法、功能特性、作用机理、实验结果对比等方面进行归纳，并指出其存在的问题。最后，总结了镁基骨植入物表面改性面临的问题，并展望了未来的发展方向。 |
| 英文摘要: |
| Due to the unique degradability, excellent biocompatibility and similar density to bone, magnesium and its alloys have become the choice of biodegradable implants for orthopedic clinical applications. In recent years, surface modification technology has been fully developed to endow magnesium-based bone implants with corrosion resistance and biological functions, which is conducive to better responding to the complex clinical application environment. The work aims to review the research progress of surface modification of magnesium-based bone implants in recent years, and briefly discuss the problems and future development directions of various surface modification methods. Firstly, the background information on the clinical demand for bone implants, the performance advantages and limitations of magnesium-based implants, and the in vivo application environment were introduced. On this basis, according to the functional classification, the research progress of surface modification technology of magnesium-based bone implants was mainly described. The preparation methods, functional characteristics and mechanism of action were described respectively, and the existing problems are pointed out. Finally, the future perspectives of surface modification of magnesium-based bone implants are discussed rationally. According to their different functions, the surface modification of magnesium-based bone implants can be divided into corrosion resistant coatings, bone healing coatings, antibacterial coatings, self-healing coatings, and biological immune coatings. Corrosion resistant coatings, including micro-arc oxidation (MAO) coating, sol-gel coating and hydrothermal coating, can provide physical shielding for the substrate to resist the erosion of inorganic ions and organic substances in the bone environment, thereby effectively controlling the degradation rate of the substrate. The bone healing coatings mainly use bone healing drugs and bone-like bioactive substances to promote osteogenesis and inhibit osteoclast activity. The antibacterial coatings mainly exert antibacterial properties through metal ions (such as Ag, Ga, Zn, Cu, etc.) and antibacterial drugs (gentamicin, ciprofloxacin, vancomycin, etc.). Self-healing coatings are classified into two categories, autonomous and triggered, based on whether they achieve repair of coating damage through external intervention. The biological immune coatings mainly realize immune regulation by altering the macroscopic morphology and adding alloy elements and immunologically active factors. Existing studies have shown that the surface modification of magnesium-based bone implants can realize the introduction of biological functions on the basis of improving the corrosion resistance. However, for the complex service environment, there are few studies on the sequential function of constructing multi-stage composite coatings to achieve antibacterial and anti-infection properties in the initial stage and promote bone growth in the middle and late stages. In addition, the differences in specific implant sites and functional requirements faced by implants have not been studied in depth. In the future, the surface modification of magnesium-based bone implants is expected to achieve breakthroughs in the fields of spontaneous sequential function, customized design of service environment and refractory bone repair. |
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