王欣,田惠博,于军,刘洋,李宁,王丽丽,王苹.石墨烯基涂层的性质及在抗菌和组织工程中的应用[J].表面技术,2020,49(5):129-139.
WANG Xin,TIAN Hui-bo,YU Jun,LIU Yang,LI Ning,WANG Li-li,WANG Ping.Graphene-based Coating: Its Properties and for Antibacterial and Tissue Engineering Applications[J].Surface Technology,2020,49(5):129-139 |
| 石墨烯基涂层的性质及在抗菌和组织工程中的应用 |
| Graphene-based Coating: Its Properties and for Antibacterial and Tissue Engineering Applications |
| 投稿时间：2019-06-27 修订日期：2020-05-20 |
| DOI：10.16490/j.cnki.issn.1001-3660.2020.05.016 |
| 中文关键词: 石墨烯涂层 生物活性 抗菌膜 组织工程 生物医疗器械 |
| 英文关键词:graphene coatings bioactive antibacterial film tissue engineering biomedical device |
| 基金项目:波士顿红线项目（3R2198352416） |
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| Author | Institution |
| WANG Xin | 1.Jilin University, Changchun 130021, China; 2.Changchun University, Changchun 130022, China |
| TIAN Hui-bo | 1.Jilin University, Changchun 130021, China; 2.Changchun University, Changchun 130022, China |
| YU Jun | 1.Jilin University, Changchun 130021, China; 2.Changchun University, Changchun 130022, China |
| LIU Yang | 1.Jilin University, Changchun 130021, China; 2.Changchun University, Changchun 130022, China |
| LI Ning | 1.Jilin University, Changchun 130021, China; 2.Changchun University, Changchun 130022, China |
| WANG Li-li | 1.Jilin University, Changchun 130021, China; 2.Changchun University, Changchun 130022, China |
| WANG Ping | 1.Jilin University, Changchun 130021, China; 2.Changchun University, Changchun 130022, China |
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| 中文摘要: |
| 石墨烯材料——石墨烯纳米片（Graphene nanoflakes，GFs）、氧化石墨烯（GO）或还原氧化石墨烯（rGO）、化学气相沉积技术制备的石墨烯膜（CVD-G），自问世起，迅速成为社会各界广泛关注的新型碳纳米材料。通过转移方法或者溶剂助技术，可以将CVD-G和表面含有亲水基团的GFs或GO涂覆于基体表面，形成石墨烯基涂层，涂层以其独特的形貌、结构、物理化学性质，呈现出良好的抗菌活性和细胞外基质特点，显著影响细胞的粘附、增殖和分化等行为。经过近十年的研究，生物活性石墨烯基涂层材料在细胞培养、细胞生长、组织工程支架和生物医疗器械中展示出巨大的应用潜力。着重围绕石墨烯涂层的成分和制备方法，总结具有抗菌活性的石墨烯材料所取得的重要成果与最新进展，围绕石墨烯基二维涂层（涂覆于基底的二维表面）和石墨烯基三维结构（基底为三维支架）对多种哺乳细胞的相容性和细胞行为调控，综述了石墨烯材料在组织工程支架和植入体表面改性中的研究进展，提出了生物活性石墨烯基涂层的研制方向与应用展望等。 |
| 英文摘要: |
| Since their discovery, Graphene-based materials, i.e. graphene nanoflakes (GFs), graphene oxide (GO) or reduced GO (rGO), and graphene films produced by chemical vapour deposition (CVD-G), have been a new class of carbon nanomaterials that attracted substantial research interest. Graphene-based coatings like CVD-G (being transferred to a substrate) and a modified GFs or GO that deposited on a substrate by solvent-assisted method exhibited excellent antibacterial activity and extracellular matrix character due to its unique morphology, microstructure, and physicochemical cues to enable cell attachment, proliferation, and differentiation. Over the past decade, studies have increasingly reported on the bioactive graphene-based coatings that showed great potential for the cell culture, cell-growth, tissue engineering scaffold, and biomedical devices. In this review, we summarize recent great advances of antibacterial graphene-based coatings in view of composition and fabrication methods. In addition, mammalian cell behaviors on 2D graphene-based coatings and 3D scaffolds for tissue engineering and implants are compiles as well. Future perspectives and emerging challenges are also highlighted. |
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