周长春,叶兴江,肖占文,王哲,张兴栋.磷酸钙骨组织工程支架表面微纳米化改性研究[J].表面技术,2014,43(4):82-85.
ZHOU Chang-chun,YE Xing-jiang,XIAO Zhan-wen,WANG Zhe,ZHANG Xing-dong.Micro / Nano-modification of Calcium Phosphate Bone Tissue Engineering Scaffold[J].Surface Technology,2014,43(4):82-85 |
| 磷酸钙骨组织工程支架表面微纳米化改性研究 |
| Micro / Nano-modification of Calcium Phosphate Bone Tissue Engineering Scaffold |
| 投稿时间：2014-03-04 修订日期：2014-05-05 |
| DOI： |
| 中文关键词: 骨组织工程支架 多孔磷酸钙陶瓷 水热法 晶须 表面微纳米改性 |
| 英文关键词:bone tissue engineering scaffolds porous calcium phosphate ceramics hydrothermal method whisker surface micro / nano-modification |
| 基金项目:国家自然科学基金重大项目(81190131) ;国家重点基础研究发展计划(973 计划,2011CB606201) |
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| Author | Institution |
| ZHOU Chang-chun | National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China |
| YE Xing-jiang | National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China |
| XIAO Zhan-wen | National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China |
| WANG Zhe | National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China |
| ZHANG Xing-dong | National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China |
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| 中文摘要: |
| 目的 研究多孔磷酸钙骨组织工程支架的表面微纳米化改性。 方法 通过双氧水发泡法制备多孔磷酸钙骨组织工程支架,利用水热法对材料进行微纳米化表面改性。 通过扫描电镜观察材料的显微结构,通过 X 射线衍射仪分析测试材料改性层相成分。 结果 材料改性处理后,孔隙率为( 63 ± 8 ) % ,大孔孔径为(310 ±30 ) μm。 材料表面及内孔壁生成羟基磷灰石微纳米晶粒或晶须,晶须长 20 ~ 40 μm,直径为 100 ~ 300 nm。 结论 多孔磷酸钙陶瓷材料的内外表面经水热法处理微纳米化表面改性后,材料性能得到提升。 |
| 英文摘要: |
| Objective To research the surface micro / nano-modification of porous calcium phosphate bone tissue engineering scaffolds. Methods Porous calcium phosphate bone tissue engineering scaffolds were prepared by the H2 O2 foaming method. Then the hydrothermal method was applied for the surface micro / nano-modification. The scanning electron microscopy ( SEM) was used for microstructure observations, and the X-ray diffraction ( XRD) was used to analyze the phase composition of the modified layer. Results After the surface modification, scaffolds with a total porosity of ( 63 ± 8 ) % , and a pore size of ( 310 ± 30 ) μm were obtained. The modified surface layers were hydroxyapatite nanocrystals or whiskers, the length of whisker ranged 20 ~ 40 μm, and the diameter was in range of 100 ~ 300 nm. Conclusion The inner and outer surfaces of porous calcium phosphate scaffolds formed a micro / nano-modification layer by hydrothermal treatment. The performance of the material was improved. KEY WORDS: |
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